在早期诊断青光眼中分析两只眼睛之间的不对称性,将从视网膜图像和OCT中提取的特征结合到分类模型中
Francisco Rodríguez-Robles1, Rafael Verdú-Monedero1, Rafael Berenguer-Vidal2
1Departamento de Tecnologías de la Información y las Comunicaciones, Universidad Politécnica de Cartagena, 30202 Cartagena, Spain.
Sensors (Basel, Switzerland)
|July 11, 2023
概括
使用光学连贯断层扫描 (OCT) 和视网膜底部图像分析眼睛的不对称性,有助于早期诊断青光眼. OCT不对称的特征显示出更高的诊断性能,而不是 fundus 图像检测青光瘤.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 计算生物学 计算生物学
背景情况:
- 青光眼的诊断通常依赖于检测单一眼中的微妙变化.
- 双眼间不对称性分析为早期发现青光眼提供了一种新的方法.
- 对比视网膜底部图像和光学连贯性断层扫描 (OCT) 对于不对称度量至关重要.
研究的目的:
- 评估视网膜底部图像和OCT用于早期绿眼病诊断的眼睛间不对称性的有效性.
- 使用这些不对称性特征来比较决策树和支向量机的诊断能力.
- 根据不对称性来确定哪种成像模式在青光眼的检测中提供了卓越的性能.
主要方法:
- 从视网膜底部图像中提取的杯/盘比和光边宽度不对称.
- 从OCT扫描中测量了视网膜神经纤维层厚度不对称性.
- 开发和比较分类模型 (决策树,SVM) 使用不对称性特征用于青光眼的检测.
主要成果:
- 经过优化分类模型的使用,通过使用OCT不对称性特征 (灵敏度80.9%,特异性88.2%) 实现了更高的性能.
- 视网膜底部图像不对称的特征显示了较低的,但仍然有用的,对玻璃眼查的性能.
- 在两种模式中的某些不对称特征之间观察到线性关系.
结论:
- 间眼不对称性分析,特别是使用OCT,是区分健康个体和青光眼患者的宝贵工具.
- 与视网膜底部图像衍生的指标相比,来自OCT的不对称度量提供了优越的诊断性能.
- 两种成像方式的不对称性特征都可以作为有效的玻璃眼指标.
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