习惯性行走的电皮质动力学和计划在帕金森病中跨越障碍物的计划
Rodrigo Vitório1,2,3, Ellen Lirani-Silva4, Diego Orcioli-Silva1,2
1Institute of Biosciences, Sao Paulo State University (UNESP), Rio Claro 13506-900, Brazil.
Sensors (Basel, Switzerland)
|July 11, 2023
概括
患有帕金森病 (PD) 的人在行走时表现出大脑活动的改变,在感觉运动皮质中增加了低频脑电波. 皮肤病影响皮层控制,需要更大的传感运动集成来进行移动和避开障碍.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 生物医学工程 生物医学工程
背景情况:
- 帕金森病 (PD) 的特点是运动障碍.
- 这些步行障碍背后的特定神经机制仍然不清楚.
- 了解PD行走期间的皮质活动对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了比较PD患者与健康对照者之间的正常行走和避开障碍物的电皮活动.
- 在PD中识别与步态控制和平衡调整相关的独特大脑模式.
- 调查传感运动集成在PD调节运动中的作用.
主要方法:
- 使用64通道移动电脑电图 (EEG) 系统记录大脑活动.
- 分析了15名PD患者和14名健康老年人的头皮EEG数据.
- 采用k-means集群用于独立组件分析和在各种频段 (alpha,beta,gamma) 和alpha/beta比率中的量化功率.
主要成果:
- 与对照人群相比,患有PD的个体在正常行走期间在左感觉运动皮质中表现出更高的α/β比率.
- 在障碍物接近时,两组都显示出阿尔法和β功率下降,马功率增加,反映出平衡和视觉需求.
- 只有患有PD的人在接近障碍物时,左感觉运动皮质的α功率和α/β比率降低.
结论:
- 帕金森病会影响正常行走的皮质控制,由感觉运动皮质中低频神经元活动的增加表明.
- 避障规划改变了电皮层的动态,突出了增加的平衡和视觉处理需求.
- 患有PD的个体似乎依赖于增强的感觉运动集成来应对运动挑战.
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