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对结核相关黑色素瘤与新发黑色素瘤相比,皮肤显微镜的比较评估
European journal of dermatology : EJD
|July 11, 2023
概括
皮肤镜回归可能表明在位神经关联黑色素瘤 (NAM) 超过新的黑色素瘤 (DNM). 虽然皮肤镜目前对分化不可靠,但在非典型病变附近的回归证明了对NAM的怀疑.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 使用皮肤镜检查,区分在位神经相关的黑色素瘤 (NAM) 和新发黑色素瘤 (DNM) 仍然具有挑战性.
- 目前用于区分这些黑色素瘤亚型的皮肤显微镜标准是不确定的.
研究的目的:
- 为了研究和比较 in situ NAM 与 in situ DNM 的皮肤学特征.
- 识别特定的皮肤学标记物,以帮助区分这两种疾病.
主要方法:
- 现场黑色素瘤成年患者的回顾性观察性研究.
- 黑色素瘤的分层分为NAM和DNM组.
- 两组之间的临床和皮肤镜数据的比较.
主要成果:
- 分析了183名在位黑色素瘤患者;129人进行了标准化皮肤镜像.
- 非典型的色素网络,非典型的血球和回归是常见的特征.
- 与DNM (33.3%) 相比,NAM (54.9%) 的皮肤镜回归发生频率明显高 (p=0.016).
- 多变量分析证实回归是NAM (OR=2.34) 的重要预测因素.
结论:
- 目前对NAM与DNM的皮肤镜评估是不可靠的.
- 在非典型病变旁边的皮肤镜回归的存在应该引起对in situ NAM的怀疑.
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