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通过尿素功能化的推拉染色体有效地清除氧化,调节无介导疾病

Himadri Shekar Roy¹, Neethu K M², Swati Rajput³

¹Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, 140306, Punjab, India.

Chemistry (Weinheim an der Bergstrasse, Germany)

|July 11, 2023

概括

新的尿素功能化染色体作为氧化 (NO) 清除剂,转化为稳定的NONOates. 这些分子对感知和治疗NO介导疾病充满希望.

科学领域:

化学化学化学
生物医学科学生物医学科学
材料科学材料科学材料科学

背景情况:

过多的氧化 (NO) 有助于各种病理状况.
目前用于抑制NO生产的策略在临床上取得了有限的成功.
开发有效的NO吸尘器对于管理NO介导疾病至关重要.

研究的目的:

开发新的尿素功能化染色体作为氧化 (NO) 清除剂.
调查NO清理的机制和产生的产品的特性.
评估这些新型分子在NO中介条件下的潜在治疗应用.

主要方法:

用1,1,4,4-四亚诺布塔-1,3-二烯 (TCBD) 或扩展TCBD (eTCBD) 的尿素功能推拉染色体的合成.
核磁共振 (NMR) 研究以阐明NO结合后的反应机制.
使用LPS激活细胞对NO清除活性进行体外评估.
在卡拉基南诱导的脚胀和角膜损伤模型中对治疗功效的体内评估.
用于传感应用的-eTCBD的排放性质的表征.

主要成果:

尿素功能化染色体有效地清理多余的NO,形成稳定的NONOates.
尿素-eTCBD具有独特的排放特性,使其能够作为体外NO传感器使用.
细胞相容的尿素-eTCBD迅速使激活细胞释放的NO无活化.
在炎症和损伤的临床前模型中证明了治疗疗效.

结论:

尿素功能化染色体代表了一种有前途的策略,用于清理多余的NO.
尿素-eTCBD提供了作为NO传感器和治疗剂的双重功能.
这些发现支持对各种NO介导疾病的这种分子的探索.

关键词:

没有食者.抗血管原性抗血管原性这是一种抗炎药物.氧化氧化是一种氧化.推-拉色素体的染色体

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