主报告多伦多强迫症度量表 (TOCS) 的临床验证:一个儿科开源的评级度量表
Laura J Lambe1, Christie L Burton1, Evdokia Anagnostou2,3
1Program of Neurosciences and Mental Health Hospital for Sick Children Toronto Ontario Canada.
JCPP advances
|July 11, 2023
概括
多伦多强迫症量表 (TOCS) 是诊断儿童和青少年强迫症的可靠工具. 它有效地将强迫症与ADHD和ASD区分开来,有助于临床和研究应用.
科学领域:
- 精神病学和心理学 精神病学和心理学
- 神经发育障碍 神经发育障碍
- 儿童和青少年心理健康 儿童和青少年心理健康
背景情况:
- 现有的强迫症 (OCD) 措施缺乏跨境疾病研究和临床评估的多用途实用性.
- 需要一个可靠的,定量性的强迫症评级尺度,适用于各种患者群体.
- 多伦多强迫症尺度 (TOCS) 是作为强迫症特征的家长报告测量标准而开发的.
研究的目的:
- 评估Toronto强迫症尺度 (TOCS) 的心理测量属性.
- 使用接收器操作特征 (ROC) 分析,为TOCS建立临床切断点.
- 评估TOCS区分强迫症 (OCD),注意力缺陷/多动症 (ADHD) 和自闭症谱系障碍 (ASD) 的能力.
主要方法:
- 对TOCS的心理测量特性 (确认因素分析,可靠性,有效性) 在350名强迫症儿童和青少年的样本中进行了检查.
- 采用接收器运行特征 (ROC) 分析,使用发现和验证样本建立TOCS临床切线.
- 在强迫症,多动症 (n=820) 和自闭症 (ASD) 组 (n=794) 中,与典型发展的对照组 (n=391) 进行了分类准确性和TOCS评分的比较.
主要成果:
- TOCS 显示了强迫症与对照者的优异诊断区分 (AUC ≥0.95,敏感度 77%-92%,特异性 92%-98%).
- 建立的TOCS截止值在一个独立的验证样本中实现了85%-90%的分类准确性.
- TOCS有效地将强迫症与ADHD (AUC ≥0.86) 和ASD (AUC ≥0.81) 区分开来,在大多数维度中,强迫症组的得分更高.
结论:
- 父母报告TOCS是评估青少年强迫症特征的可靠和有效措施.
- TOCS在区分强迫症与对照,ADHD和ASD方面表现出强烈的敏感性和特异性.
- TOCS是临床评估,跨界疾病研究和儿科精神健康人口研究的有价值的定量工具.
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