家庭对喘和ADHD的责任:基于瑞典国家登记册的研究
Shihua Sun1, Ralf Kuja-Halkola1, Zheng Chang1
1Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden.
JCPP advances
|July 11, 2023
概括
喘和注意力缺陷/多动障碍 (ADHD) 具有共同的遗传风险因素,导致家族共同聚合. 一种疾病的家族史需要对另一种疾病进行评估,强调共同的遗传基础.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 儿科 儿科 儿科
背景情况:
- 喘和ADHD显示报告的关联,但共同的遗传病因仍然不清楚.
- 调查家族共同聚合和遗传与环境影响的平衡至关重要.
研究的目的:
- 检查喘和ADHD的家族共同聚合模式.
- 量化遗传和环境因素对它们同时发生的相对贡献.
主要方法:
- 使用瑞典国家登记处对927,956个人的队列进行了调查.
- 使用后勤回归来进行关联和联合聚合分析.
- 应用双变异双胞胎建模来估计遗传和环境相关性.
主要成果:
- 喘显著增加了ADHD的风险 (OR 1.50).
- 单胞胎双胞胎的家族共同聚合最强,随着遗传亲属关系的减少而减少.
- 双变异遗传性很高 (0.88),喘和ADHD之间存在显著的遗传相关性 (0.12).
结论:
- 喘和ADHD在家庭中共同聚集,主要是由于共同的遗传因素.
- 对一种疾病的临床评估应考虑另一种疾病,因为共同的家庭责任.
- 建议对共同发生的特定遗传变异进行进一步的研究.
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