产前酒精暴露和儿童睡眠问题:一项基于家庭的准实验性研究
Ingunn Olea Lund1,2, Eivind Ystrom1,3,4
1Department of Mental Disorders Norwegian Institute of Public Health Oslo Norway.
JCPP advances
|July 11, 2023
概括
怀孕期间母亲饮酒与儿童睡眠问题有关. 然而,这种联系并非因果关系,因为家庭和环境因素解释了这种联系,而不是饮酒的直接影响.
科学领域:
- 围产期健康 围产期健康
- 儿童发展 儿童发展
- 生殖毒理学 生殖毒理学
背景情况:
- 在怀孕的第一季度,产前暴露于危险的酒精消费对儿童发育造成了担忧.
- 研究母亲饮酒与后代睡眠问题之间的联系对于理解发育影响至关重要.
研究的目的:
- 确定母亲在怀孕早期的危险饮酒与儿童睡眠问题之间的关联是否是因果关系.
- 区分酒精对睡眠结果的直接影响和混因素.
主要方法:
- 利用来自挪威母亲,父亲和儿童队列研究 (MoBa) 和挪威医疗出生登记处 (MBRN) 的大量基于人口的样本 (15,911名母亲,30,395名后代).
- 采用兄弟姐妹设计和仪器变量分析来控制测量和未测量的家族混因素.
- 通过怀孕17周和30周的自我报告评估母亲的酒精消费,以及孩子在1.5岁和3岁时的睡眠问题.
主要成果:
- 孕妇在第一季度饮酒危险的母亲的孩子在1.5岁和3岁时出现睡眠问题的风险增加.
- 当控制家族风险因素和测量环境混因素时,这些关联减少到无意义的水平.
- 兄弟姐妹分析表明,家庭因素,而不是直接的酒精影响,解释了观察到的关联.
结论:
- 怀孕期间母亲的危险饮酒与后代在三岁之前的睡眠问题之间的中等关联在很大程度上是由共同的家族风险因素解释的.
- 这些发现表明,观察到的关联并不代表母亲饮酒和儿童睡眠障碍之间的直接因果关系.
- 这项研究强调了在对产前暴露和儿童发育的研究中考虑家庭和环境混因素的重要性.
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