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在一般儿科患者中,T细胞与注意力问题之间的关联:R世代研究
Kirsten I M Looman1,2, Charlotte A M Cecil3,4,5, Christina Grosserichter-Wagener6
1Generation R Study Group Erasmus MC University Medical Center Rotterdam The Netherlands.
JCPP advances
|July 11, 2023
概括
增加的T助手1 (Th1) 和CD8+T细胞与儿童更多的注意力问题相关. 这表明,亲炎性免疫特征可能会导致注意力困难.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 神经科学是一个神经科学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 的确切原因尚不清楚.
- 慢性免疫激活,由T和B细胞水平表明,是注意力问题的潜在因素.
研究的目的:
- 调查T和B细胞子集与儿科人口注意力问题之间的关联.
- 探索免疫系统激活在注意力障碍病理生理学的作用.
主要方法:
- 分析了756名来自R世代队伍的10岁儿童.
- 流细胞计测用于评估周围血液中的T和B细胞子集.
- 父母报告的注意力问题使用儿童行为检查清单进行测量.
主要成果:
- 在T助手1 (Th1) 细胞中,一个标准偏差的增加与注意力问题得分增加5.3%有关.
- CD8+ T 细胞的标准偏差增加1个与注意力问题得分增加7.5%有关.
- 提升的天真和中央记忆CD8+ T细胞也与更高的注意力问题得分相关.
结论:
- 较高的Th1和细胞毒性T细胞数量与儿童注意力问题增加有关.
- 这些发现表明,在儿童注意力障碍中,一种促炎性免疫特征可能起作用.
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