相关实验视频

Updated: Jul 23, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

循环RNA:白血病的一个新星

Qianan Li¹, Xinxin Ren¹, Ying Wang¹

¹College of Life Sciences, Zhejiang Normal University, Jinhua, China.

|July 11, 2023

概括

循环RNAs (circRNAs) 是涉及瘤进展的非编码RNA. 本综述详细介绍了它们在白血病中的作用,包括免疫调节,化学抵抗,以及作为诊断和预后生物标志物的潜力.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
在RNA生物学,RNA生物学.

背景情况:

非编码RNAs (ncRNAs) 缺乏蛋白质编码潜力.
循环RNAs (circRNAs) 是一种具有独特的共价循环结构的ncRNAs的新型类.
在各种人类癌症中观察到异常的circRNA表达,包括白血病.

研究的目的:

审查不同类型白血病中circRNAs的表达和功能.
阐明circRNAs对免疫调节和白血病化学抵抗的影响.
探索circRNAs作为白血病的诊断和预后标记物的潜力.

主要方法:

对白血病中circRNAs现有研究的文献综述.
对详细描述各种白血病亚型中circRNA表达模式的研究进行分析.
综合关于circRNA参与细胞过程的发现,如增殖,亡,迁移和自.

主要成果:

循环RNAs在白血病中异常表达,并影响关键的癌症相关途径.
循环RNAs在调节白血病的免疫反应和化学抵抗中发挥着重要作用.
新出现的证据凸显了circRNAs作为白血病诊断和预后的敏感生物标志物的潜力.

结论:

循环RNA是白血病发育和进展的关键调节者.
循环RNA为改善白血病诊断,预后和治疗策略提供了有希望的途径.
进一步的临床前研究对于验证circRNAs作为白血病的可靠体内生物标志物至关重要.

关键词:

生物标志物生物标志物化学抗药性化学抗药性是一种抗药性.免疫调节免疫调节在白血病中,白血病.环RNA 环RNA 是一个环RNA.

更多相关视频

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...