抗疟疾药物耐药性:在印度尼西亚传播的简要历史
Loeki Enggar Fitri1,2, Aulia Rahmi Pawestri1,2, Nuning Winaris1,2
1Department of Parasitology Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Drug design, development and therapy
|July 11, 2023
概括
印度尼西亚的抗疟疾药物耐药性对疟疾消除目标构成重大威胁. 了解耐药机制对于制定未来有效的治疗指南和控制计划至关重要.
科学领域:
- 热带医学是一种热带医学.
- 分子流行病学分子流行病学
- 药物耐药性机制 药物耐药性机制
背景情况:
- 疟疾仍然是印度尼西亚的主要公共卫生挑战,目标是到2030年消除疟疾.
- 抗疟疾药物耐药性威胁到国家控制计划,增加发病率和死亡率.
- 抗克洛洛昆,硫胺-胺和普里马昆的耐药性在Plasmodium falciparum和Plasmodium vivax中广泛存在.
研究的目的:
- 审查抗疟疾药物耐药性的机制.
- 突出印尼抵抗运动的发展和传播.
- 为未来的治疗指南和疟疾控制策略提供信息.
主要方法:
- 审查关于抗疟疾药物耐药性的现有文献.
- 对与药物耐药性相关的分子标记物的分析.
- 检查药物耐药性出现的历史趋势.
主要成果:
- 除了美西宁外,所有抗疟疾药物类别都出现了耐药性.
- 特定的基因变异 (pfmdr1, pfcrt, dhfr, dhps, pfk13) 与耐药性有关.
- 1974年报道了对氨酸的耐药性,1979年报告了硫素-甲胺的耐药性,后来出现了广泛的失败.
结论:
- 了解耐药机制对于有效控制疟疾至关重要.
- 遗传标记器提供了对抗性模式的洞察力.
- 未来的战略必须应对广泛的抗疟疾药物耐药性的挑战.
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