兄弟姐妹和双胞胎激素转移对自闭症特征没有影响
Melanie M de Wit1, Sander Begeer1,2, Michel G Nivard2,3
1Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam the Netherlands.
JCPP advances
|July 11, 2023
概括
这项研究没有发现有双胞胎兄弟会增加女孩的自闭症特征的证据,反驳了双胞胎激素转移假说. 在这项大型双胞胎双胞胎研究中,兄弟姐妹对自闭症特征的影响很小.
科学领域:
- 发展心理学 发展心理学
- 行为遗传学 行为遗传学
- 神经科学是一个神经科学.
背景情况:
- 兄弟姐妹关系,包括双胞胎和非双胞胎的动态,可能会影响自闭症特征.
- 双胞胎丸激素转移假说假设产前丸激素暴露会影响男性双胞胎女孩的自闭症特征.
研究的目的:
- 研究双胞胎和非双胞胎兄弟姐妹对自闭症特征的产前和产后影响.
- 为了检查兄弟性别在调节双胞胎双胞胎中自闭症特征中的作用.
主要方法:
- 在7714个双胞胎双胞胎中,使用母亲和老师的报告分析了自闭症特征.
- 用回归模型来评估双胞胎性别和年长/年轻兄弟姐妹性别的影响.
主要成果:
- 双胞胎兄弟的女孩的母亲报告的自闭症特征略低,但这在教师报告中没有发现.
- 在男孩的自闭症特征和他们的双胞胎性别之间没有发现任何显著的关联.
- 在有大哥哥的女孩中观察到教师报告的自闭症特征的小幅增加;其他兄弟姐妹的影响是可以忽略不计的.
结论:
- 研究结果不支持双胞胎激素转移假设,该假设是双胞胎男生女孩中自闭症特征增加.
- 有限的证据表明,出生前和出生后兄弟姐妹对自闭症特征的影响很小.
- 结果与自闭症谱系障碍 (ASD) 的高遗传性和缺乏共同环境影响相一致.
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