相关实验视频
Updated: Jul 23, 2025

07:56
Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
11.6K
在血液恶性瘤中发烧的非传染性原因. 抗生素是否仍然适用?
Zainab Shahid1, David J Epstein2
1Memorial Sloan Kettering Cancer Center, New York, NY.
Current opinion in infectious diseases
|July 11, 2023
概括
血造细胞移植 (HCT) 和CAR-T治疗患者的发烧通常有非传染性原因. 优化抗生素的使用和降级对于管理这些复杂的病例和预防不良事件至关重要.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 发烧是血液细胞移植 (HCT) 和仿真抗原受体T细胞 (CAR-T) 治疗接受者的常见并发症.
- 识别发烧的各种病因,包括非传染性综合征,对于适当的临床管理至关重要.
研究的目的:
- 审查在HCT和CAR-T接受者中引起发烧的常见非传染性综合征.
- 讨论这些复杂的患者群体的最佳诊断和抗生素管理策略.
- 强调抗菌药物管理和抗生素降级的重要性.
主要方法:
- 在HCT和CAR-T接受者的非传染性发烧原因的文献综述.
- 分析目前诊断和管理的最佳实践.
- 对抗微生物药物管理原则和降级策略的评估.
主要成果:
- 非传染性综合征是HCT和CAR-T接受者发烧的常见原因.
- 抗生素降级是一种安全有效的策略,可以减轻不良事件,包括Clostridioides difficile感染 (CDI),多药耐药生物 (MDROs) 和微生物组失调.
- 对非传染性病因的认识指导了适当的抗生素使用.
结论:
- 临床医生必须在免疫受损患者中识别非传染性发烧原因.
- 实施明智的抗生素使用和降级策略可以改善患者的治疗结果,并减少与抗菌素有关的毒性.
相关概念视频
Increased Body Temperature
714
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
714
Types of Fever
419
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
419
Disorders of Leukocytes
984
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
984
Methods of reducing fever
705
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
705
Tonsillitis II: Management
139
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
139
Patterns of Fever
2.7K
Before understanding the types and patterns of fever, it is essential to know its phases.
2.7K

