肝脂肪量化的临床实用性,用于确定2型糖尿病患者心血管疾病风险
Selena Z Kuo1,2, Sandra Cepin1, Jaclyn Bergstrom1
1NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.
Alimentary pharmacology & therapeutics
|July 11, 2023
概括
较高的肝脂肪增加了2型糖尿病患者心血管疾病的风险. 肝脂肪量化可以改善对2型糖尿病患者的心血管疾病风险评估.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 和2型糖尿病 (T2DM) 是心血管疾病 (CVD) 的独立风险因素.
- 在T2DM患者中评估心血管疾病风险对于有效管理至关重要.
研究的目的:
- 评估肝脂肪量化的临床实用性,以确定T2DM患者中心血管疾病风险.
- 调查肝脏脂肪含量与已确定的心血管疾病风险得分之间的关联.
主要方法:
- 对年龄≥50岁的T2DM成年人前景队列的横截面分析.
- 使用磁共振成像检测质子密度脂肪分数 (MRI-PDFF) 量化的肝脂肪.
- 患者分为较高 (≥14.6%) 和较低 (<14.6%) 的肝脂肪群;通过弗雷明汉和ASCVD得分评估心血管疾病风险.
主要成果:
- 在多变量分析中,较高的肝脂肪与心血管疾病风险增加 (OR=4.04) 和ASCVD风险评分 (OR=2.85) 有显著的关联,独立于年龄,性别,种族和BMI.
- 该研究包括391名成年人 (66%为女性),平均年龄为64岁,BMI为30.8公斤/米2.
结论:
- 肝脏脂肪含量增加独立地增加T2DM患者心血管疾病的风险.
- 肝脂肪量化可能会增加这一群体中心血管疾病风险的分层.
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