在与酒精相关的肝病中,尿路托芬代谢物发生变化
Raobo Xu1,2,3,4, Vatsalya Vatsalya2,5, Liqing He1,2,3,4
1Department of Chemistry, University of Louisville, Louisville, Kentucky, USA.
Alcohol, clinical & experimental research
|July 11, 2023
概括
与健康个体相比,在酒精相关性肝病 (ALD) 患者的尿中托芬代谢物水平不同. 特定的代谢物,林酸和硫酸,显示与ALD严重程度有很强的相关性,提供潜在的诊断标记.
科学领域:
- 生物化学 生物化学
- 代谢学 代谢学 代谢学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 酒精相关性肝病 (ALD) 是一个主要的全球健康问题,诊断生物标志物有限.
- 托 (Trp) 代谢在生理过程中至关重要,但其在ALD中的改变尚未完全理解.
- 尿液分析提供了一种非侵入性的方法来发现ALD生物标志物.
研究的目的:
- 为了研究ALD患者和健康对照者之间尿液Trp代谢物的差异.
- 为了确定尿液Trp代谢物是否可以区分轻度/中度和严重的ALD.
- 为了确定ALD严重程度的潜在尿路生物标志物.
主要方法:
- 从健康对照组 (n=18),非严重的ALD (n=21) 和严重的酒精相关肝炎 (n=25) 患者的尿液中量化Trp及其代谢物.
- 采用非向和向的代谢学技术进行综合分析.
- 在两个代谢平台上验证的发现.
主要成果:
- 在尿样中鉴定和量化了17-18 Trp代谢物.
- 在ALD严重程度组中,总体Trp度没有显著差异.
- 在健康对照组和ALD患者之间观察到九种Trp代谢物的显著差异.
- 关联了十个Trp代谢物的丰度与末期肝病模型 (MELD) 的得分.
结论:
- 与健康人相比,ALD患者的尿路Trp代谢发生变化.
- 两种特定的Trp代谢物,林酸和硫酸,与ALD严重程度高度相关.
- 这些代谢物代表了评估ALD进展的有希望的尿路生物标志物.
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