社会经济不平等和年轻成人衰老的分子风险
American journal of epidemiology
|July 11, 2023
概括
社会经济地位 (SES) 与年轻人的生物衰老标志物有关. 较低的SES与转录和免疫通路中的加速衰老特征相关,突出显示了早期生活中的差异.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 生物衰老的表现不同,通常受社会经济地位 (SES) 的影响.
- 生命早期的SES差异可能会在临床症状出现之前影响衰老轨迹.
- 转录组衰老特征提供了一个分子镜头来研究衰老过程.
研究的目的:
- 调查社会经济地位 (SES) 指标与年轻成年期基于mRNA的衰老特征之间的关联.
- 探索可能的调解机制,将SES与转录基因衰老联系起来.
- 确定SES在早期衰老中影响的特定生物途径.
主要方法:
- 利用了来自青少年至成人健康国家纵向研究 (第五波,2016-2018年) 的数据.
- 分析了来自2,491名年龄在33-43岁之间的成年人的转录组数据.
- 使用复合的转录基因特征和路径子集测量生物衰老;通过收入,教育,职业和主观状态评估SES.
主要成果:
- 社会经济地位 (SES),特别是综合措施和收入,显示出与转录性衰老有显著的关联.
- 包括免疫,线粒体,核糖体,溶酶体和蛋白质体功能在内的特定途径与SES有关.
- 调解模型表明,BMI,吸烟,保险,财务压力和压力等因素部分解释了SES与衰老的关系.
结论:
- 社会经济地位 (SES) 与衰老的分子标志物有关,即使在年轻成年时也是如此.
- 参与衰老的多个生物学途径在晚年之前已经受到SES的影响.
- 这些发现强调了解决社会经济差异的重要性,以缓解早期的生物衰老.
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