在怀孕期间的口腔微生物组和跨王国相互作用
C Gilbert Klaczko1,2, N Alkhars2,3, Y Zeng4
1Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Journal of dental research
|July 11, 2023
概括
怀孕改变了口腔微生物组,增加了高风险群体的口腔疾病风险. 在怀孕期间,Veillonella rogosae显示出作为健康口腔微生物群的生物标志物的潜力.
科学领域:
- 微生物学 微生物学
- 口腔健康 口腔健康
- 孕产妇健康 孕产妇健康
背景情况:
- 怀孕显著改变了母亲的口腔微生物组,可能会增加口腔疾病的风险,特别是在西班牙裔/黑人妇女和那些社会经济地位较低 (低SES) 的妇女中.
- 了解这些转变对于开发针对高风险孕妇群体的有针对性的干预措施至关重要.
研究的目的:
- 在低SES孕妇的口腔微生物组 (细菌和真菌) 的特征.
- 为了确定特定的微生物与口腔健康指标的关联,如牙和斑块指数.
主要方法:
- 收集了179名孕妇和28名非孕妇低SES的非刺激的唾液和上膜斑样.
- 评估了细菌 (16S rRNA) 和真菌 (18S ITS) 社区.
- 进行了牙腐烂和斑块指数的口腔检查.
主要成果:
- 在孕妇和非孕妇之间观察到细菌丰度的显著差异.
- 突变性菌株,口腔菌株和乳杆菌菌与牙腐烂的增加有关.
- 在斑块 (Candida) 和唾液 (Malassezia) 中发现了不同的真菌群落 ("菌类").
- Veillonella rogosae与斑块指数和唾液 Candida albicans 有负相关性,并且在体外抑制了C. albicans.
结论:
- Veillonella rogosae显示出潜力作为一个生物标志物,用于怀孕妇女的noncariogenic口腔微生物组.
- 特定的细菌和真菌物种与怀孕期间的口腔健康状况有关.
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