系统性硬化症对牙周健康的影响:一项病例对照研究
Sophie Jung1,2,3, Marianna Gavriiloglou1,4, François Séverac5
1Faculté de Chirurgie Dentaire Robert Frank, Université de Strasbourg, Strasbourg, France.
Journal of clinical periodontology
|July 11, 2023
概括
系统性硬化症 (SSc) 与更宽的牙周带 (PDL) 空间和更差的口腔健康有关. 这项研究发现,SSc患者的PDL表面增加和炎症生物标志物升高,影响了他们的生活质量.
科学领域:
- 口腔医学是指口腔医学.
- 类风湿病学 类风湿病学
- 放射学 放射学是一门学科.
背景情况:
- 系统性硬化症 (SSc) 呈现出各种口腔表现.
- 在扩散皮肤SSc (dcSSc) 和有限皮肤SSc (lcSSc) 中精确评估口腔特征是有限的.
研究的目的:
- 与对照组相比,评估SSc患者的牙周带 (PDL) 表面.
- 评估SSc患者的口腔健康相关的生活质量 (OHRQoL) 和牙裂液 (GCF) 生物标志物.
主要方法:
- 在39名SSc患者和39名对照组中进行了标准化口腔检查和形光束计算机断层扫描 (CBCT).
- 在GCF中测量了互白素-6 (IL-6),CXCL-4和矩阵金属蛋白酶-9 (MMP-9) 的水平.
- 使用CBCT量化了PDL表面,并使用SSc尺度 (MHISS) 的口腔障碍评估了OHRQoL.
主要成果:
- 在SSc患者中,PDL表面增加,缺失的牙更多,IL-6,MMP-9和CXCL-4水平更高.
- 在dcSSc中注意到减少了口腔开口,但没有lcSSc. 在dcSSc中,MHISS得分更高.
- 两个SSc亚组的牙周参数都比对照组更差,但dcSSc患者的牙炎症较少.
结论:
- 系统性硬化症与牙周带带空间的扩大有关.
- SSc显著损害了患者的口腔健康和与口腔健康相关的生活质量.
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