雌激素疗法用于治疗绝经后妇女的骨盆器官脱落
Annika Taithongchai1, Eugenie E Johnson2,3, Sharif I Ismail4
1Department of Obstetrics and Gynaecology, King's College Hospital, London, UK.
The Cochrane database of systematic reviews
|July 11, 2023
概括
证据不足以结论雌激素治疗在绝经后妇女的骨盆器官脱落 (POP) 的益处. 需要进一步的研究来确定其在管理POP症状中的有效性和成本效益.
科学领域:
- 妇科 妇科 妇科 妇科
- 泌尿和妇科 泌尿和妇科
- 老年医学 老年医学
背景情况:
- 骨盆器官脱落 (POP) 影响了许多绝经后的女性,风险因素包括年龄,平价和BMI.
- 本综述侧重于雌激素治疗在绝经后妇女管理POP中的作用.
研究的目的:
- 评估局部和全身雌激素治疗对绝经后妇女POP症状的益处和危害.
- 要总结对POP雌激素治疗的经济评估.
主要方法:
- 搜索了多个数据库,包括Cochrane失禁专业注册,CENTRAL和MEDLINE,截至2022年6月.
- 包括随机对照试验 (RCT) 评估雌激素治疗 (单独或联合) 与安慰剂,不治疗或其他干预措施对POP.
主要成果:
- 确定了14项涉及1002名女性的研究;大多数有偏见的高风险.
- 数据不足阻止了计划中的子组分析和仅仅对雌激素治疗的结论.
- 局部雌激素与阴囊显示较少的阴道不良事件; 通过手术,它减少了手术后的尿路感染,但由于研究异质性,研究结果需要谨慎解释.
结论:
- 没有足够的RCT证据来证实雌激素治疗对绝经后妇女的POP的益处或危害.
- 需要进行更大规模的研究来评估雌激素治疗的有效性和成本效益,单独或与其他治疗相结合,用于POP管理.
- 未来的研究应该专注于POP治疗的中长期结果.
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