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第一代与第二代自动化胰岛素输送系统在患有1型糖尿病的儿童群体中的现实世界表现:为期一年的观察性研究
Bruno Bombaci1, Stefano Passanisi1, Mariella Valenzise1
1Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi," University of Messina, Messina, Italy.
Journal of diabetes science and technology
|July 11, 2023
概括
第一代和第二代自动化胰岛素输送 (AID) 系统显示,在患有1型糖尿病的儿童和青少年中,持续的血糖控制. 先进的混合闭环系统 (AHCL) 与混合闭环系统 (HCL) 相比,提供更严格的血糖指数目标和更好的可用性.
科学领域:
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
- 生物医学工程 生物医学工程
背景情况:
- 在儿科患者中1型糖尿病的管理带来了独特的挑战.
- 自动化胰岛素输送系统 (AID) 提供了改善血糖控制的潜力.
- 第一代和第二代AID系统的现实性能数据对于临床采用至关重要.
研究的目的:
- 评估第一代 (混合闭环,HCL) 和第二代 (先进混合闭环,AHCL) 自动化胰岛素输送系统的实际有效性.
- 为了比较一个多年的1型糖尿病儿童和青少年的HCL和AHCL系统之间的血糖结果和可用性.
主要方法:
- 单中心观察性研究,包括54名儿童和青少年 (7-18岁) 转换到AID治疗.
- 追溯收集基线,6个月和12个月的人口,临床和持续血糖监测 (CGM) 数据.
- 统计分析比较HCL和AHCL用户之间的血糖指标,系统设置和胰岛素需求.
主要成果:
- 两周后,AHCL使用者在范围内的时间,范围以上的时间,传感器平均葡萄糖和血糖风险指数明显改善,与HCL使用者相比.
- 在12个月后,AHCL使用者保持了传感器平均葡萄糖和葡萄糖管理指标的优势.
- HCL和AHCL系统都实现了推的临床目标,AHCL系统显示了自动模式激活的增加和手动模式调整的减少.
结论:
- 第一代和第二代AID系统都在儿童1型糖尿病中提供持续的血糖控制.
- 先进的混合闭环 (AHCL) 系统可以实现更严格的血糖目标,而不会增加低血糖风险.
- 增强的可用性和AHCL系统的持续自动模式激活有助于达到最佳的血糖指数.
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