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基于山羊奶的婴儿配方奶粉对生长和安全参数的影响:系统性审查和元分析

Mateusz Jankiewicz¹, Linde van Lee², Mirthe Biesheuvel³

¹Department of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, Poland.

|July 11, 2023

概括

基于山羊奶的婴儿配方奶粉 (GMF) 和基于牛奶的婴儿配方奶粉 (CMF) 显示出类似的婴儿生长和安全结果. 这次系统性审查发现,GMF和CMF之间在体重,长度或头部周长方面没有显著差异. 这两种配方都是安全的,婴儿也能很好地容忍它们.

科学领域:

儿童营养学儿童营养学
胃肠病学胃肠病学
临床试验临床试验

背景情况:

基于山羊奶的婴儿配方奶粉 (GMF) 在全球范围内越来越多.
监管批准意味着它们的潜在用途可以作为牛奶配方 (CMF) 的替代品.
关于婴儿生长和安全的GMF和CMF的比较证据需要进行系统的评估.

研究的目的:

系统地评估GMF与CMF对婴儿生长参数的比较影响.
在婴儿中,与CMF相比,评估GMF的安全性和耐受性.
综合 GMF 与 CMF 养的随机对照试验 (RCT) 的发现.

主要方法:

在MEDLINE,EMBASE和Cochrane图书馆数据库中进行系统的文献搜索 (截至2022年12月).
包括4项随机对照试验 (RCT),涉及670名婴儿.
使用修订的柯克兰偏差风险工具 (ROB-2) 进行偏差风险评估;异质性由I2.2量化.

主要成果:

在受GMF和CMF养的婴儿之间,没有观察到体重,长度或头部周长的性别和年龄调整的z-score的显著差异.
便频率在GMF和CMF组之间是可比的.
严重和不严重的不良事件在两个养组中都相似,表明可比的安全概况.

结论:

基于山羊奶的婴儿配方奶粉 (GMFs) 和基于牛奶的婴儿配方奶粉 (CMFs) 对于婴儿生长一样安全和耐受.
这些发现为使用GMF作为CMF可行的替代品提供了保证.
可能需要进一步的研究来澄清便的一致性差异,尽管整体安全性得到了支持.

关键词:

孩子们的孩子们的孩子们的孩子们.养养养养一只山羊,一只山羊.增长的增长增长的增长增长的增长.婴儿婴儿婴儿婴儿婴儿婴儿婴儿婴儿配方奶粉的使用方法营养营养营养营养

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