出生缺陷与神经细胞起源和儿科胚胎瘤之间的关联
Eugene C Wong1, Philip J Lupo2, Tania A Desrosiers1
1Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Cancer
|July 11, 2023
概括
患有神经细胞起源的出生缺陷 (BDNCOs) 的儿童面临患胚胎瘤的风险明显更高. 这一发现表明,共同的发育路径可能是这些条件的基础,为未来的研究和监测提供信息.
科学领域:
- 发展生物学 发展生物学
- 儿科瘤学 儿科瘤学
- 遗传学 遗传学 是一个
背景情况:
- 关于出生缺陷与神经细胞发育起源 (BDNCOs) 和胚胎瘤之间的关联存在有限的研究.
- 胚胎瘤与神经细胞具有共同的分子特征,这表明潜在的共同病因路径.
研究的目的:
- 估计BDNCOs对胚胎瘤风险的影响.
- 探索BDNCOs和胚胎瘤之间潜在的共同遗传起源和病因途径.
主要方法:
- 采用了多州,注册表链接队列研究设计.
- 考克斯回归模型用于计算BDNCO与胚胎瘤相关的危险比率 (HRs) 和95%置信区间 (CI).
- 包括BDNCOs:耳朵,脸部,部缺陷,赫施普隆病,先天性心脏缺陷. 胚胎瘤:神经母细胞瘤,神经母细胞瘤,肝母细胞瘤.
主要成果:
- 与没有出生缺陷的儿童相比,患有BDNCO的儿童患有胚胎瘤诊断的可能性是4.2倍.
- BDNCOs与肝母细胞瘤 (HR, 16.1) 有着强烈的关联,以及神经母细胞瘤 (HR, 3.1) 和神经母细胞瘤 (HR, 2.9) 的风险增加.
- 根据婴儿的性别,母亲的种族/种族,母亲的年龄或母亲的教育,没有观察到显著的风险变化.
结论:
- 患有BDNCO的儿童患有胚胎瘤的风险增加.
- 发育途径的共同破坏可能会导致BDNCO和胚胎瘤.
- 这些发现可以指导未来的基因组研究和癌症监测这些条件.
更多相关视频
07:43An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery
Published on: August 23, 2016
10.0K
09:33Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
Published on: October 3, 2019
10.9K
相关概念视频
Determination
18.6K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.6K
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Neurulation
42.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.1K
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
