饮食微量元素和神经退行性疾病的发病因子
Masahiro Kawahara1, Midori Kato-Negishi1, Ken-Ichiro Tanaka1
1Department of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo 202-8585, Japan.
Nutrients
|July 11, 2023
概括
铁 (Fe), (Zn),铜 (Cu) 和 (Mn) 等微量元素对大脑功能至关重要,但过量会导致损伤. 它们的双相稳定与神经退行性疾病有关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
背景情况:
- 微量元素 (铁,,铜,) 对于大脑功能至关重要.
- 这些金属的过度含量可以产生反应性氧物种并损伤大脑组织.
- 金属平衡的失调与神经退行性疾病 (如阿尔茨海默氏症和子疾病) 有关.
研究的目的:
- 审查基本 (Fe, Zn, Cu, Mn) 和非基本 (Al) 元素的摄入,吸收和运输.
- 探索这些金属与神经退行性疾病的发病之间的联系.
- 检查金属蛋白和金属金属相互作用在神经退行症中的作用.
主要方法:
- 文献综述侧重于金属稳态和神经退行.
- 分析现有关于微量元素代谢和运输的研究.
- 综合有关金属-蛋白质和金属-金属交叉交谈在疾病发病过程中的数据.
主要成果:
- 基本的微量元素被吸收,运送到大脑,并对其功能至关重要.
- 金属低温和多余的金属 (特别是 Zn 和 Cu) 导致神经退行和血管痴呆症.
- 氨基原蛋白质会影响金属的稳态,而金属诱导的蛋白质错折会加剧神经毒性.
结论:
- 微量元素平衡对于预防脑损伤和神经退行至关重要.
- 了解金属-蛋白和金属-金属相互作用是阐明神经退行性疾病机制的关键.
- 对金属dyshomeostasis的进一步研究为神经系统疾病提供了治疗潜力.
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