通过胎盘运输的人造甜味剂
Magnus Leth-Møller1,2,3, Christina Søndergaard Duvald2, Sofie Stampe1,2
1Department of Obstetrics and Gynecology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus Nord, Denmark.
Nutrients
|July 11, 2023
概括
怀孕期间消耗的人造甜味剂穿过胎盘,到达胎儿循环和羊水. 这种胎盘转移可能解释了与母亲人工甜味剂摄入相关的儿童肥胖风险增加.
科学领域:
- 围产期营养学 围产期营养学
- 发展性毒理学 发展性毒理学
- 孕产妇和胎儿的医学
背景情况:
- 肥胖率的上升凸显了需要了解代谢功能障碍的胎儿起源.
- 建议孕妇使用人工甜味剂,而不是含糖饮料.
- 新出现的证据将母亲的人工甜味剂消费与儿童肥胖风险的增加联系在一起.
研究的目的:
- 研究人工甜味剂在胎儿循环和羊水中通过胎盘转移到胎儿循环和羊水中.
- 为了确定孕妇摄入的人造甜味剂是否会到达胎儿.
主要方法:
- 19名孕妇在剖腹产前接受了口服剂量的乙硫,环酸盐,糖和糖.
- 在手术期间采集了母体血,胎儿血和羊水样本.
- 人工甜味剂度使用质谱学量化.
主要成果:
- 所有四种测试的人造甜味剂 (乙硫,环酸盐,糖,糖) 都被检测到胎儿循环中.
- 观察到所有甜味剂的母体和胎儿血度之间存在线性关系.
- 在羊水中也发现了甜味剂,尽管与胎儿血没有直接的线性关系.
结论:
- 人造甜味剂很容易通过胎盘进入胎儿循环.
- 这些甜味剂在胎儿血和羊水中的存在,为不良发育影响提供了潜在的机制.
- 研究结果表明,需要重新评估怀孕期间使用人工甜味剂的建议.
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