面条摄入量与代谢综合征之间的积极因果关系:两样本的孟德尔随机化研究
Sunmin Park1, Meiling Liu1,2
1Obesity/Diabetes Research Center, Department of Food and Nutrition, Hoseo University, Asan 31499, Republic of Korea.
Nutrients
|July 11, 2023
概括
在亚洲成年人中,高面食量与代谢综合征 (MetS) 和其组成部分 (包括高血压和肥胖) 的风险增加有关. 这一发现突显了饮食对代谢健康的潜在影响.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 代谢健康研究 代谢健康研究
背景情况:
- 面食消费与代谢综合征 (MetS) 之间的关系仍在争论中.
- 之前的观察性研究表明存在联系,但因果关系的证据有限.
研究的目的:
- 调查面条消费与MetS及其成分风险之间的潜在因果关系.
- 使用双样本的门德尔随机化 (MR) 方法来进行可靠的因果推理.
主要方法:
- 采用两个样本的门德尔随机化 (MR) 设计,使用遗传变异作为面条摄入量的工具变量.
- 分析了来自大型成人队列 (城市医院和AAR) 的数据与全基因组关联研究 (GWAS) 数据的数据.
- 应用各种MR方法 (IVW,MR-Egger,加权中位数) 并进行灵敏度分析以评估结果的有效性.
主要成果:
- 高面摄入量与饮食质量差有关,包括更高的能量,脂肪,蛋白质,和血糖负载.
- 观察性分析显示,总和特定的面条摄入类型与MetS风险之间存在积极的关联.
- 核磁共振分析,特别是IVW模型,表明高面食摄入因果性地增加了MetS,高血压,失脂症,高血糖症,高三糖血症和腹部肥胖症的风险.
结论:
- 面条的消费表明与代谢综合征及其个体成分的风险存在积极的因果关系.
- 研究结果表明,减少面条摄入量可能对亚洲成年人群的代谢健康有益.
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