多基因风险评分,生活方式和2型糖尿病风险:中国前性队列研究
1Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University (Wuxi Center for Disease Control and Prevention), Wuxi 214023, China.
Nutrients
|July 11, 2023
概括
对2型糖尿病 (T2D) 的多基因风险评分 (PRS) 有效地识别出高风险的中国人. 健康的生活方式显著降低了高PRS患者的T2D风险,有助于早期查和预防.
科学领域:
- 遗传学和流行病学
- 代谢性疾病 研究 研究 研究
背景情况:
- 2型糖尿病 (T2D) 在全球范围内构成了重大公共卫生挑战.
- 准确识别2型糖尿病高风险个体对于有针对性的干预至关重要.
- 现有的风险预测模型可能无法完全捕捉不同人群中的遗传倾向.
研究的目的:
- 在中国队列中开发和验证T2D的多基因风险评分 (PRS).
- 评估PRS在确定个人进行生活方式干预方面的实用性.
- 评估PRS,生活方式因素和T2D风险之间的相互作用.
主要方法:
- 从无锡非传染性疾病队列的5024名参与者中80种遗传变异的基因定型.
- 在14年的长度随访中,确定了440例新的T2D病例.
- 考克斯回归分析以确定PRS相关性和危险比率.
- 评估生活方式因素,包括吸烟,酒精,运动,饮食,BMI和腰围.
主要成果:
- 在东亚人中发现的包含46个单核酸多态 (SNP) 的PRS与未来T2D风险有显著的关联.
- 在PRS最高五分之一的人群中,T2D风险与底部五分之一人群相比增加了两倍 (HR:2.06).
- 采用理想的生活方式 (4-6个健康因素) 将高PRS个体的10年T2D发病率减半 (6.77%至3.28%).
- 整合PRS改善了风险分层,识别高PRS的临床风险较低的个体具有T2D风险较高.
结论:
- 开发的46-SNP PRS是识别中国人群中T2D高风险个体的宝贵工具.
- PRS增强了传统的临床风险因素,使得T2D风险分层更加精确.
- 促进健康的生活方式可以减轻对T2D的遗传倾向,突出早期查和个性化预防策略的潜力.
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