微血管功能,炎症状况和氧化应激在重量回收后的患者中
Karynne Grutter Lopes1,2,3, Maria das Graças Coelho de Souza1,2,3, Eliete Bouskela1,2,3
1Obesity Unit, Centro de Pesquisas Clínicas Multiusuário (CePeM), Hospital Universitário Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de Janeiro 20550-013, RJ, Brazil.
即使在减肥手术后重量显著增加,患者仍然保持了一些代谢和炎症益处,与对照组相比,血管健康得到保护.
科学领域:
- 心血管科学 心血管科学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 减肥手术改善了肥胖症中的心血管健康.
- 关于重量恢复对手术后血管健康的影响的数据有限.
研究的目的:
- 为了比较代谢,炎症,氧化状态和血管功能,在高体重恢复后的患者中与非手术对照进行比较.
主要方法:
- 经过Roux-en-Y胃绕道术的患者重量恢复率高 (RWR) 和匹配的对照进行了临床评估.
- 测量了循环生物标志物 (代谢,炎症,氧化应激).
- 用静脉闭塞复合镜和激光光斑对比成像来评估内皮和微血管反应性.
主要成果:
- 腹患者的子周长较低,葡萄糖和甘油三,以及高的HDL胆固醇.
- 没有观察到内皮/微血管反应或关键炎症/氧化应激标志物的显著差异.
- 在减肥组中,阿迪波内克的含量更高,互白素-6的含量更低.
结论:
- 体重重回高的病后患者保留了部分代谢和炎症的好处.
- 尽管重量恢复,血管功能仍然与非手术对照相比较.
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