异质性脂质血症和脂质三合体之间的关系以及评估胰岛素抵抗力的尺度

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Hernán Paublini^1,2, Angel Arturo López González^1,2, Carla Busquets-Cortés^1,2

¹Research Group Adema Salud IUNICS, 07003 Palma, Spain.

Nutrients

|July 11, 2023

概括

胰岛素抵抗风险尺度有效地识别了动脉动脉性脂质失调症 (AD) 和脂质三位一体 (LT). 甘油三 / HDL 量表显示了这些脂质疾病的最高预测准确度.

科学领域:

内分泌学在内分泌学.
心血管医学心血管医学
代谢综合征是代谢综合征的一种.

背景情况:

动脉性脂质失调症 (AD) 和脂质三位一体 (LT) 与胰岛素抵抗 (IR) 有关.
这些脂质变化加速动脉样硬化,这是导致死亡的主要原因.
IR是AD发展的一个重要因素.

研究的目的:

为了研究动脉性脂质失调症 (AD) 和脂质三位一体 (LT) 和胰岛素抵抗 (IR) 风险尺度之间的关系.
评估IR风险尺度用于识别AD和LT的预测效用.

主要方法:

一项对418,343名工人的横截面研究.
根据三种IR风险尺度评估AD和LT:甘油三/HDL,TyG指数和METS-IR.
使用ROC曲线来确定IR尺度的预测精度 (AUC,灵敏度,特异性).

主要成果:

高IR风险的患病率在患有AD和LT的人群中明显高.
在ROC分析中,所有三种IR尺度的预测性能都很好或非常好 (AUC为0.8560.991).
甘油三/高血糖平衡表现出最高的AUC,接近1.

结论:

在AD/LT和评估的IR风险尺度之间存在着很强的关系.
在AD和LT患者中观察到更高的平均IR值和患病率.
推METS-IR用于估计胰岛素耐药性,而甘油三/HDL为AD/LT提供了最佳预测.

关键词:

有机脂性血清不良症 (atherogenic dyslipidaemia) 是一种致血性血清不良症.无源性风险无源性风险胰岛素耐药性是一种胰岛素耐药性.脂质三合一的三位一体

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