维生素D受体基因多态与西班牙裔心脏代谢表型的关联:一生的方法
Carrie S Standage-Beier1, Luis A Garcia2, Eleanna De Filippis3
1School of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA.
维生素D受体 (VDR) 基因变异与西班牙裔人的心脏代谢健康有关. VDR SNPs与血压和BMI等特征之间的关联在儿童和成人之间有所不同.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 维生素D受体 (VDR) 对平衡和骨代谢至关重要.
- 新出现的证据强调了VDR在代谢性疾病中的作用.
- 以前的研究将VDR单核酸多态 (SNPs) 与非西班牙裔白人心脏代谢表型联系起来,但西班牙裔的数据有限.
研究的目的:
- 研究西班牙裔人口中VDR SNPs和心脏代谢特征之间的关联.
- 确定这些关联是否在各年龄组之间存在差异.
主要方法:
- 在1610名自报西班牙裔中对VDRSNP (Taq1,Fok1,Apa1) 进行基因型关联分析.
- 用于评估与心脏代谢特征的关联的线性回归模型.
- 对儿童 (<18岁) 和成年人 (≥18岁) 的年龄分层分析.
主要成果:
- 在儿童中,Taq1和Apa1SNP与缩血压 (SBP) 有关.
- 在儿童中,Fok1 SNP与脂肪度量 (脂肪量,腰围,BMI) 有关.
- 在成年人中,Taq1与血红蛋白A1c相关,Apa1与BMI和禁食葡萄糖相关. 在Fok1中,没有显著的成年人关联.
结论:
- 在西班牙裔人口中,VDR SNPs与各种心脏代谢表型有关.
- 这些VDR SNP协会的性质和力量因年龄组而异.
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