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格拉布里丁通过通过p38 MAPK/Nrf2/NF-κB通路减少氧化应激和炎症来改善酒精引起的肝损伤

Mengyao Wang¹, Feng Zhang¹, Jie Zhou¹

¹College of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.

|July 11, 2023

概括

来自甘的格拉布里丁 (Gla) 通过对抗炎症和氧化应激,有效地减少酒精性肝损伤. 这种天然化合物显示为酒精性肝病 (ALD) 的新疗法.

科学领域:

药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.
自然产品化学化学

背景情况:

酒精性肝病 (ALD) 是与慢性饮酒有关的重大健康问题.
甘草根含有格拉布里丁 (Gla),一种具有已知的抗氧化和抗炎性质的异黄.
关于Gla在减轻ALD治疗潜力的研究有限.

研究的目的:

在小鼠模型和HepG2细胞中研究格拉布里丁 (Gla) 对乙醇诱导的肝损伤的保护作用.
阐明Gla的肝保护作用背后的分子机制,重点关注氧化应激,炎症和关键信号通路.

主要方法:

在C57BL/6J小鼠和乙醇处理的HepG2细胞中使用了利伯-德卡利乙醇饮食模型.
评估肝损伤标志物,血清炎症性细胞因子,活性氧物种 (ROS),亡和抗氧化酶活性.
研究了p38 MAPK,Nrf2和NF-κB信号通路的参与,使用异粒素作为p38 MAPK激动剂.

主要成果:

格拉显著缓解了乙醇诱导的肝损伤,减少了真空化和脂质积累.
在小鼠中,Gla治疗降低了血清炎症性细胞因子水平,减弱了ROS和亡.
在体外,Gla抑制了NF-κB的核转位,并促进了Nrf2的核转位,这种效应在一定程度上被阿尼索米辛逆转.

结论:

格拉布里丁 (Gla) 对抗酒精性肝损伤表现出显著的肝保护作用.
该机制涉及调节p38 MAPK/Nrf2/NF-κB通路,减少氧化应激和炎症.
格拉具有作为一种新型治疗剂或健康产品来治疗酒精性肝病 (ALD) 的潜力.

关键词:

格拉布里丁 (Glabridin) 是一种可怕的药物.在 NF-κBB 中.Nrf2 没有任何问题.酒精性肝损伤导致的肝损伤这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.p38 MAPKK 的时间.

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