与高体脂质量相关的高费里水平影响腹腔透析患者的死亡率
Hyung Seok Lee1, Hye-Mi Noh2, Jung Nam An1
1Department of Internal Medicine & Kidney Research Institute, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of Korea.
Nutrients
|July 11, 2023
概括
腹腔透析 (PD) 患者的高费里丁水平与体脂肪增加有关. 这种脂肪有助于提高PD患者的死亡风险,突出显示肥胖和不良结果之间存在关键联系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 临床营养学 临床营养学
背景情况:
- 腹腔透析 (PD) 患者中普遍存在肥胖症,通常与血清费里丁水平升高相关.
- 在PD患者中高血清费里的预后意义仍在争论中,研究结果相互矛盾.
- 增加脂肪是高费里水平的潜在驱动因素,可能会影响PD患者的治疗结果.
研究的目的:
- 为了研究增加脂肪对PD患者血清费里水平的影响.
- 确定高费里水平与营养良好的PD患者全因死亡率之间的关联.
- 确定高费里的临床决定因素,特别关注人体成分.
主要方法:
- 研究了一组350名营养良好的腹透析患者.
- 用便携式全身生物阻抗光谱仪评估身体组成.
- 测量了血清费里水平,并分析了与身体脂肪百分比,瘦组织指数和死亡率的关联,平均30个月的随访时间.
主要成果:
- 18.0%的患者表现出高水平的费里 (≥600 ng/mL).
- 患有高费里的患者体脂百分比较高,瘦组织指数较低.
- 高酸盐含量 (≥600 ng/mL) 与所有原因死亡率的增加有显著关联,独立于瘦组织指数和体积状态.
结论:
- 脂肪增加是腹腔透析患者高血清费里丁水平的重要决定因素.
- 由脂肪量增加引起的血清费里含量升高与PD患者因任何原因死亡的风险更高有关.
- 管理脂肪可能对改善PD患者高费里水平的临床结果至关重要.
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