肠道微生物群的组成可能是长期饮食模式的有用指标吗?
Karin Šik Novak1, Nives Bogataj Jontez1, Ana Petelin1
1Faculty of Health Sciences, University of Primorska, Polje 42, 6310 Izola, Slovenia.
Nutrients
|July 11, 2023
概括
在属级的肠道微生物群组成不能可靠地表明饮食模式,除了纯素饮食. 其他生活方式因素对于预测肠道微生物群和健康标志物更为重要.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 饮食显著影响肠道微生物群的组成.
- 关于特定饮食模式与肠道微生物群之间的关系的研究有限.
- 了解这种联系对于个性化的营养和健康策略至关重要.
研究的目的:
- 调查肠道微生物群组成是否可以作为长期饮食模式的可靠指标.
- 探索肠道微生物特征对不同饮食 (无食,素食,素食,低碳水化合物/高脂肪) 的预测能力.
- 为了确定影响肠道微生物群组成的关键因素,除了饮食之外.
主要方法:
- 在四个饮食组的89名受试者中使用16S rRNA基因元编码对肠道微生物组组成的分析.
- 在基因层面应用k-means集群和最接近邻居分类器来预测饮食模式.
- 多变量分析包括人类学,临床,生活方式和心理因素.
主要成果:
- 在属级的肠道微生物群组成一般没有预测饮食模式.
- 纯素饮食是一个例外,其特点是大量的Prevotella 9*.
- 26个变量 (生活方式,临床,心理因素,营养) 的组合预测了微生物群集的准确率为91%,超过了单纯的饮食摄入量.
结论:
- 肠道微生物群的组成不是大多数饮食模式的强大的独立生物标志物.
- 针对肠道健康的饮食干预可能需要考虑更广泛的生活方式改变.
- 未来的战略可以专注于优化可修改的生活方式因素,以改善与特定肠道微生物群个人资料相关的健康标志物.
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