炎症通路的功能障碍及其与厌食症神经症患者的抗下垂体自身抗体的关系
Andrea Amerio1,2, Andrea Escelsior1,2, Eleonora Martino2,3
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16126 Genoa, Italy.
Nutrients
|July 11, 2023
概括
神经性厌食症 (AN) 患者表现出增加的促炎性细胞因子和针对下丘脑抗原的自身抗体. 这种炎症似乎随着疾病的进展而减少,IL-21可能刺激免疫自身反应.
科学领域:
- 神经免疫学 神经免疫学
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 神经性厌食症 (AN) 的确切原因尚不清楚,但在神经精神疾病中越来越多地认识到免疫系统的激活.
- 研究AN中的免疫反应可能会揭示对疾病机制的新见解.
研究的目的:
- 检查AN患者的免疫应答标志物.
- 为了确定对下丘脑抗原和炎症的自身抗体之间的关联.
- 探索炎症标志物与AN持续时间之间的关系.
主要方法:
- 用ELISA套件测量了22名AN患者的干白素 (IL) -6,IL-1β,瘤坏死因子 (TNF) -α,转化生长因子 (TGF) -β和IL-21的血清水平.
- 对下丘脑抗原的自身抗体进行了定量评估.
- 患者没有接受心理药物治疗或自身免疫性疾病.
主要成果:
- 在AN患者中观察到显著增加的IL-6,IL-1β,TNF-α和TGF-β水平.
- 在体质指数,对下丘脑抗原的自身抗体和细胞因子水平之间发现了正相关性.
- 随着AN持续时间的推进,细胞因子水平下降.
- 在AN患者中增加的IL-21水平与自身抗体度负相关.
结论:
- 在AN中增加的亲炎性标志物与向下丘脑抗原的自身抗体相关.
- 在AN中,随着疾病持续时间的延长,预炎症状态似乎会减少.
- 介质素-21可能刺激免疫反应并增强AN中的自动反应.
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