有或没有短宫的孕妇的阴道微生物组
Angela Silvano1, Niccolò Meriggi2, Sonia Renzi2
1Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, 50139 Florence, Italy.
Nutrients
|July 11, 2023
概括
阴道微生物组的组成在宫短的妇女中不同,这是早产的风险. 特定的细菌,如Staphylococcus和Pseudomonas更为普遍,而Lactobacillus和Bifidobacterium与正常的宫长度有关.
科学领域:
- 生殖生物学 生殖生物学
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
背景情况:
- 宫缩短是早产的已知危险因素之一.
- 阴道微生物组对于怀孕结果至关重要.
- 了解与子宫长度相关的微生物变化对于母亲和胎儿的健康至关重要.
研究的目的:
- 为了研究阴道微生物组合的孕妇与短宫 (≤25毫米) 与正常宫长度 (>25毫米) 的孕妇相比.
- 为了确定与怀孕期间宫缩短相关的特定细菌种群.
主要方法:
- 使用16S rRNA基因测序分析了68名宫短的女性和29名对照女性的阴道微生物组.
- 使用R.环境进行了统计分析.
- 细菌类,属和群体之间的物种丰度的比较分析.
主要成果:
- 在所有参与者中,Firmicutes是占主导地位的类.
- 蛋白质细菌和Actinobacteriota的丰度在宫短的妇女中更高.
- 总体细菌丰富度在短宫组较低,有较少常见的种群的丰富.
- 在短宫组中,葡萄球菌和 Pseudomonas 菌更为普遍.
- 乳杆菌和Bifidobacterium与正常的宫长度有关.
- 乳杆菌jensenii和Gardnerella vaginalis与宫的缩短有关.
结论:
- 阴道微生物组的改变,包括潜在的致病性细菌的增加,与怀孕期间的宫缩短有关.
- 这些发现表明,阴道微生物组在导致早产的机制中可能发挥作用.
- 准微生物失生症可能为预防早产提供新的策略.
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