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SIGLEC10巨细胞通过抑制CD8T细胞功能来驱动胃癌的进展

Yixian Guo¹, Shouyu Ke², Feng Xie^3,4

¹GI Division, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200025, China.

Cancer immunology, immunotherapy : CII

|July 11, 2023

概括

在巨细胞上SIGLEC10抑制了胃癌中T细胞的功能. 阻止SIGLEC10可能会增强免疫疗法,并预测患者的预后.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

目前以T细胞为中心的免疫检查点抑制剂在胃癌 (GC) 中有效性有限.
巨细胞免疫检查点SIGLEC10在GC中没有明确的作用.
瘤相关巨细胞 (TAMs) 是GC瘤微环境中的关键参与者.

研究的目的:

为了研究SIGLEC10在胃癌免疫力中的作用.
确定SIGLEC10是否是GC免疫治疗的潜在治疗标.
评估GC中SIGLEC10+巨细胞的预后价值.

主要方法:

在GC组织中对CD68+巨细胞SIGLEC10表达的分析.
在体外实验中评估SIGLEC10对CD8+T细胞增殖和功能的影响.
在体外和体内研究评估SIGLEC10阻断的影响.
在SIGLEC10+巨细胞和GC患者预后之间的相关性分析.

主要成果:

在GC中,SIGLEC10主要表达在CD68+巨细胞上.
SIGLEC10通过Akt/P38/Erk通路抑制CD8+T细胞的增殖和功能.
在ex vivo和in vivo模型中,SIGLEC10阻塞增强了CD8+T细胞效应器功能.
高SIGLEC10+巨细胞透与不良的GC预后相关.

结论:

在胃癌微环境中,SIGLEC10直接抑制T细胞功能.
SIGLEC10代表了GC免疫疗法的一个有前途的新目标.
SIGLEC10+巨细胞可以作为GC临床结果的预测生物标志物.

关键词:

CD6868是什么意思 CD6868是什么意思在 CD8+ T 细胞中.胃癌胃癌是指胃癌.巨细胞是一个巨细胞.在SIGLEC10中,你会看到一个字母.

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