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相关概念视频

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

60.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

8
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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相关实验视频

Updated: Jul 23, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
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A Novel Method: Super-selective Adrenal Venous Sampling

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库希综合症:一个回顾

Martin Reincke1, Maria Fleseriu2

  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität, Munich, Germany.

JAMA
|July 11, 2023
PubMed
概括

由于皮质醇水平长期高, 每年会有2到8万人患有库辛综合征. 治疗包括手术,药物或辐射治疗这种内分泌疾病.

科学领域:

  • 内分泌学
  • 内部医学

背景情况:

  • 库希综合征涉及长期升高的血皮质醇,而不是由于生理原因.
  • 虽然外源性类固醇使用很常见,但内源性皮质醇过量产生每年影响2-8人.
  • 相关疾病包括高血糖,高血压,体重增加和情绪障碍.

研究的目的:

  • 定义库辛综合征及其原因.
  • 概述高皮质醇症的诊断方法
  • 详细介绍库辛综合征的治疗策略.

主要方法:

  • 查包括24小时尿液自由皮质醇,深夜唾液皮质醇或甲抑制测试.
  • 血皮质激素水平不同于上腺和垂体.
  • 图像检查 (MRI,状鼻取样,上腺/身体扫描) 可以确定瘤的来源.

主要成果:

  • 库希氏病是脑下垂体瘤的原因,占内源病例的60-70%.
  • 典型的症状包括皮肤变化 (斑块,斑纹) 和代谢问题 (高血糖,高血压).
  • 诊断评估排除了外源性类固醇,并局部化了皮质醇的过度产生.

结论:

  • 内源性库辛综合征的第一线治疗是手术切除瘤.

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  • 药物治疗,放射治疗或双侧上腺切除术是不响应病例的选择.
  • 有效的治疗需要解决皮质醇过剩的原因.