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一个简单的框架来区分"个人主义"和"统一的年龄增长率"在研究群体内或研究群体之间
Hans Degens1,2, Gladys L Onambélé-Pearson3
1Department of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Institute of Sport, Manchester Metropolitan University, Manchester, UK. h.degens@mmu.ac.uk.
GeroScience
|July 11, 2023
概括
一个新的框架表明,老龄化速度在个人之间有很大差异. 分析生理数据显示,大多数人年龄独特,不像表现出更统一的衰老模式的运动大师.
科学领域:
- 老年学和生理学.
- 生物统计学和数据分析
背景情况:
- 衰老涉及生理功能的下降,关于这种下降是否在人口中是统一的还是高度个性化的争论仍在进行中.
- 纵向研究是追踪老龄化率的理想方法,但需要大量资源和时间.
- 横截面数据分析为评估老化统一性提供了一个潜在的替代方案.
研究的目的:
- 提出一个新的框架,用横截面数据来评估衰老的统一性.
- 在人口中区分"高度个人主义"和"统一"的衰老模式.
- 将框架应用于生理数据,特别是肌肉力量,功率和身体功能.
主要方法:
- 开发了一个框架,分析随年龄而变化的生理参数的标准偏差 (SD) 和变化系数 (COVAR).
- 在SD和COVAR变化中确定了标志着均或个性化的衰老的特定模式.
- 将框架应用于现有已发布的数据集,重点关注与肌肉相关的功能.
主要成果:
- 均的老龄化率是由一个稳定的COVAR下降的SD表示的.
- 由于COVAR的变化,SD的变化或没有变化,表明一个高度个性化的衰老率.
- 对肌肉力量,功率和身体功能数据的分析主要表明高度个性化的衰老模式,在运动大师中注明了例外.
结论:
- 拟议的框架提供了一种方法,通过横截面数据来评估衰老的统一性.
- 大多数人表现出高度个性化的衰老轨迹,挑战了统一衰老的概念.
- 运动大师可能代表一个与普通人口相比,老龄化过程更为均的人群.
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