头骨运动的方向和频率对人类大脑机械脆弱性的影响
Ruth J Okamoto1, Jordan D Escarcega2, Ahmed Alshareef3
1Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, One Brookings Drive, MSC 1185-208-125, St. Louis, MO 63130.
Journal of biomechanical engineering
|July 11, 2023
概括
通过磁共振弹性学 (MRE) 来测量大脑中的应变能量和动能. 应变能量与动能 (SE/KE) 的比率因负载方向和频率而异,表明大脑对冲击的脆弱性.
科学领域:
- 生物力学 生物力学
- 神经成像是一种神经成像.
- 医学物理 医学物理
背景情况:
- 磁共振弹性图 (MRE) 用于评估大脑的机械特性.
- MRE测量组织运动,提供关于大脑对外部负载的反应的见解.
- 了解大脑变形对于预防伤害至关重要.
研究的目的:
- 使用MRE. 估计人类大脑中的应变能量和动能.
- 描述负载方向和频率对大脑变形的影响.
- 评估应变能量与动能 (SE/KE) 的比率作为大脑脆弱性的指标.
主要方法:
- 在两个方向 (侧向和向) 用五种频率 (20-90 Hz) 对头部进行了波激发.
- 经过修改的MRI成像序列捕获了波移位场.
- 计算了应变能与动能 (SE/KE) 的比率.
主要成果:
- SE/KE比率在很大程度上取决于加载方向和频率.
- 侧面负荷导致SE/KE比率大约是头负荷的四倍.
- 在研究的最低激发频率下,SE/KE比率最高.
结论:
- SE/KE比率是一种潜在的简单而强大的无维度指标,用于评估大脑对变形和损伤的脆弱性.
- 结果与临床观察结果一致,该临床观察结果将侧面冲击与较高的受伤概率联系起来.
- 这些发现支持低频自然大脑振荡模式的概念.
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