饮食干预对心血管结果的影响:一个网络元分析
Ioannis Doundoulakis1, Ioannis T Farmakis2, Xenophon Theodoridis3
1First Department of Cardiology, National and Kapodistrian University, "Hippokration" Hospital, Athens, Greece.
Nutrition reviews
|July 11, 2023
概括
地中海饮食 (MD) 显著减少了心血管死亡和重大事件. 这种饮食模式提供了对初级和二级心血管疾病预防的保护.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 观察性研究将地中海饮食 (MD) 与心血管风险降低联系起来.
- 有限的随机对照试验 (RCT) 证据表明MD对硬心血管结果的影响.
研究的目的:
- 确定最有效的饮食干预措施来减少心血管疾病发病率和死亡率.
- 用RCT数据评估各种饮食模式的疗效.
主要方法:
- 在主要数据库 (MEDLINE,Cochrane,Embase) 中按照PRISMA指南进行系统的文献搜索.
- 在成年人群中纳入RCT,评估饮食对死亡率和心血管事件的影响.
- 使用随机效应模型进行频率主义网络元分析.
主要成果:
- 包括17个RCT,共83280名参与者.
- 地中海饮食 (MD) 是唯一的饮食模式显示显著减少心血管死亡 (RR 0.59;95% CI,0.42-0.82).
- 此外,MD还降低了主要心血管事件,心肌梗塞,心肌痛和全因死亡率的风险.
结论:
- 地中海饮食 (MD) 显示出对心血管疾病和死亡率的保护作用.
- 医学药物对初级和二级心血管疾病的预防都有效.
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