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对猫的抗纤维素催化剂治疗用途的评估

Lotta Wahldén^1,2, Giacomo Stanzani², Simone Cutler³

¹From AniCura Regiondjursjukhuset Bagarmossen, Stockholm, Sweden (L.W.).

Journal of the American Animal Hospital Association

|July 11, 2023

概括

有限的数据存在于抗纤维解毒药物,如猫的tranexamic 酸 (TXA) 和epsilon aminocaproic 酸 (EACA). 这项研究审查了它们的使用,发现了各种方案和潜在的不良事件,突出了进一步研究的需要.

科学领域:

兽医药理学兽医药理学
猫科动物医学猫科动物医学
血液静止和血栓形成

背景情况:

抗纤维解药物,包括酸 (TXA) 和氨基酸 (EACA),用于控制出血.
关于TXA和EACA在猫患者的临床应用的数据很少.
了解当前的使用模式和结果对于基于证据的兽医实践至关重要.

研究的目的:

研究TXA和EACA在猫的临床适用性.
记录与这些药物相关的剂量方案,不良事件和患者结局.
为未来对猫科动物医学中的抗纤维解药物进行前性研究奠定基础.

主要方法:

追溯性,多中心研究设计.
对2015年至2021年期间接受TXA或EACA的猫类患者医疗数据库的分析.
包括标准适用于35名猫科动物患者.

主要成果:

86%的猫使用了特兰胺酸 (TXA),14%的猫使用了氨基胺酸 (EACA).
非创伤性出血是主要症状 (54%),其次是创伤性出血 (17%) 和选择性手术 (11%).
中位数剂量为TXA的10毫克/千克,EACA的50毫克/千克;存活到出院的几率为52%.
在20%的患者中报告了不良事件,生存率各不相同.
没有确定标准化剂量方案,剂量,间隔和持续时间有显著的变化.

结论:

目前对猫的TXA和EACA的使用涉及不同的适应症和高度可变的剂量策略.
观察到潜在的不良事件,尽管由于追溯性质,很难确定因果关系.
这项研究强调了前性研究的必要性,以确定猫科动物患者的最佳抗纤维解质疗法.

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