单片药的坚持和相关的心血管结果与单片药的单独药的管理对抗高血压三重组合治疗的单独药的管理
Federico Rea1,2, Gabriella Morabito1,2, Laura Savaré1,3,4
1National Centre for Healthcare Research and Pharmacoepidemiology.
Journal of hypertension
|July 11, 2023
概括
使用单片药组合 (SPC) 治疗高血压的患者与使用多片药组合的患者相比,对抗高血压治疗的坚持明显更高. 这种改善了对三种药物SPC的坚持,在现实环境中观察到.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 高血压管理需要始终坚持复杂的药物治疗方案.
- 单片药组合 (SPC) 旨在简化治疗并提高患者的遵守性.
- 评估SPC和多药剂方案之间的现实遵守差异对于优化高血压护理至关重要.
研究的目的:
- 为了比较三药单片药物组合 (SPC) 和多片药物治疗方案的患者之间对抗高血压治疗的坚持.
- 评估治疗策略对大量患者队列药物坚持的影响.
主要方法:
- 对28210名40岁以上的患者进行了回顾性分析,使用意大利伦巴第地区 (2015-2018) 的医疗保健数据.
- 服用佩林多普林/安洛迪平/英达帕米德SPC的患者与服用血管激素转化酶抑制剂 (ACEI) /通道阻断剂 (CCB) /利尿剂 (D) 方案 (两片药片组合) 的患者进行了比较.
- 坚持性被测量为一年内覆盖日数 (PDC) 的比例;高坚持性被定义为PDC>75%.
主要成果:
- 在59%的SPC使用者中观察到高坚持,而在两片药物组合使用者中,这一比例为25%.
- 服用三种药物的SPC的患者表现出明显更高的高度坚持的可能性 (风险比:2.38,95% CI:2.32-2.44).
- 这种改善对SPC的遵守程度在不同的人口统计和并发症概况中是一致的.
结论:
- 在现实实践中,高血压的三种药物单片药物组合导致高坚持率比使用多种药物的三种药物方案更高.
- 通过SPC简化抗高血压疗法可以提高患者的遵守性,并可能改善长期治疗结果.
- 这些发现支持使用SPC作为提高高血压管理中药物坚持的策略.
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