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Updated: Jul 23, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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皮肤基因突变通过ERK/MAPK通路促进表皮细胞-介质细胞过渡和晚期黑色素瘤

Wenqiong Ma1, Zexiu Wu1, Mazaher Maghsoudloo2,3

  • 1Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

PloS one
|July 11, 2023
PubMed
概括

皮肤基因 (DMKN) 在黑色素瘤中驱动上皮层-介质细胞过渡 (EMT),与生存率差相关. 针对DMKN及其突变可能通过调节EMT信号通路提供新的个性化黑色素瘤疗法.

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