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Updated: Jul 23, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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通过 macroH2A 变体对特定的 EMT/MET 网络进行组合准,可以保护介酶身份

Dimitrios Valakos1,2, Eleftheria Klagkou1,2, Antonis Kokkalis1

  • 1Biomedical Research Foundation, Academy of Athens, Athens, Greece.

PloS one
|July 11, 2023
PubMed
概括

基因组宏H2A变体作为介质细胞状态的守门员,阻断表皮过渡并抵抗细胞重编程. 它们通过调节新型基因网络 (MSCN) 来稳定介质细胞基因表达程序.

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