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Updated: Jul 23, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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Published on: January 14, 2016

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异染色素依赖的复制压力:从IDH1/2突变体中吸取教训

Lee Zou1,2

  • 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.

Cancer research
|July 11, 2023
PubMed
概括

瘤性异酸脱酶 (IDH) 突变导致复制应激和异色素蛋白变化,使得IDH突变瘤对PARP抑制剂 (PARPi) 敏感. PARP激活对于抑制由这种压力引起的DNA损伤至关重要.

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