内微生物组合调节食道状细胞癌的化学免疫疗法反应
Hong Wu1,2,3, Xuefeng Leng2,4, Qianshi Liu1,2,3
1Department of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, P.R. China.
Cancer research
|July 11, 2023
概括
在食道癌患者中,内链球菌预测了对新辅助化疗免疫疗法 (NACI) 的反应. 这种细菌增强了CD8+T细胞的透,改善了治疗结果和生存率.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 新辅助化疗免疫疗法 (NACI) 在可切除食道状细胞癌 (ESCC) 方面表现有前途.
- 肠道微生物群通过调节肠道免疫力来影响癌症免疫治疗反应.
研究的目的:
- 调查内微生物群对ESCC患者对NACI的反应的影响.
- 为了确定与NACI治疗效率相关的特定微生物特征.
主要方法:
- 在ESCC患者中分析内微生物β-多样性.
- 微生物特征与T细胞透 (GrzB+,CD8+) 和患者存活率的相关性.
- 单细胞RNA测序以表征响应者的免疫细胞群.
- 在小鼠身上进行便微生物移植和殖民研究.
主要成果:
- 内微生物群的多样性预测了NACI治疗效率.
- 链球菌的丰富与增加的CD8+T细胞透相关,并预测了更长的无病生存期.
- 受访者显示CD8+效应器记忆T细胞较高,CD4+调节T细胞较低.
- 从响应者转移到小鼠中的微生物增强了内链球菌,增强了CD8+ T细胞,并改善了抗PD-1反应.
结论:
- 内链球菌签名可以预测ESCC中的NACI反应.
- 链球菌通过增强CD8+T细胞透促进了有利的抗PD-1治疗结果.
- 内微生物群有可能指导癌症免疫疗法策略.
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