优化ALS的药理疗法,以改善结果和生活质量
1Physician and neurologist at Neurologists of Cape Cod, Cape Cod Healthcare, in Hyannis, MA.
The American journal of managed care
|July 11, 2023
概括
目前,只有三种FDA批准的治疗方法可以减缓肌缩侧面硬化症 (ALS) 的进展. 症状管理对生活质量至关重要,新兴的疗法为未来提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 肌缩侧面硬化症 (ALS) 已经限制了FDA批准的修改疾病的治疗方法.
- 目前的治疗选择依赖于患者的特征,因为指南已经过时.
- 症状管理对于改善ALS患者的生活质量至关重要.
研究的目的:
- 审查目前FDA批准的ALS疾病修饰治疗方法.
- 强调ALS患者的症状管理的重要性.
- 讨论针对ALS的新兴治疗剂和干预措施.
主要方法:
- 对FDA批准的ALS治疗方法的文献评论.
- 对当前临床指南及其局限性的分析.
- 药理和非药理症状治疗的概述.
- 对ALS的试验药物,生物制剂和干预措施的调查.
主要成果:
- 美国食品和药物管理局批准了三种疾病修饰药物 (edaravone,riluzole,PB/TURSO);第四种药物 (tofersen) 获得了加速批准.
- 许多症状治疗方法被非标签用于管理各种ALS症状.
- 一系列新型药物,包括生物药物和干细胞疗法,正在调查中.
结论:
- 治疗ALS的景观正在随着新的批准和正在进行的研究而不断发展.
- 个性化治疗选择和综合性症状管理是关键.
- 新兴疗法对未来的ALS护理进步充满希望.
相关概念视频
Alzheimer's Disease: Treatment
219
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
219
Drug Therapy
73
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
73
Psychosis: Goals of Pharmacotherapy
170
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
170
Parkinson's Disease: Treatment
302
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
302
Alzheimer's Disease: Overview
525
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
525
Myasthenia Gravis: Overview and Treatment
1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K


