相关实验视频

Updated: Jul 23, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

4-1BB向免疫疗法:机制,抗体和化学抗原受体T

Xiaoling Shen¹, Rusong Zhang¹, Xiaojuan Nie¹

¹School of Life Sciences, Jiangsu University, Zhenjiang, China.

Cancer biotherapy & radiopharmaceuticals

|July 11, 2023

概括

4-1BB (CD137,TNFRSF9) 是癌症免疫治疗中至关重要的蛋白质. 用抗体或CAR-T细胞向4-1BB可以增强抗癌免疫反应和T细胞功能.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

4-1BB (CD137,TNFRSF9) 是一种I型跨膜蛋白,它与其连接体4-1BBL结合.
这种相互作用激活核因子-kappa B信号通路,促进T细胞的增殖和生存.

研究的目的:

在癌症免疫治疗中提供4-1BB的全面分析.
专注于4-1BB向抗体和CAR-T细胞中的4-1BB的治疗应用.

主要方法:

关于 4-1BB. 的当前科学文献的审查.
分析涉及针对4-1BB.单克隆抗体的研究.
检查4-1BB作为CAR-T细胞中辅助刺激域的作用.

主要成果:

4-1BB激活导致T细胞增殖,生存和抗亡信号的增加.
针对4-1BB的单克隆抗体用于治疗各种癌症,包括淋巴瘤和固体瘤.
将4-1BB纳入CAR-T细胞通过增强增殖和减少枯竭来提高它们的有效性.

结论:

了解4-1BB对于推进癌症免疫治疗至关重要.
针对4-1BB提供了改善癌症治疗结果的有希望的策略.
该审查强调了4-1BB在基于抗体的疗法和CAR-T细胞工程中的双重作用.

关键词:

在 4-1BBBB 中.在CAR-T细胞中.抗体是对抗体的重要组成部分.瘤治疗的治疗方法

更多相关视频

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...