亚临床甲状腺功能低下症,脏和心脏从正常到尿性环境
Nereida Spahia1, Merita Rroji1, Myftar Barbullushi1
1Department of Nephrology, University Hospital Center "Mother Teresa," Tirana, Albania.
Metabolic syndrome and related disorders
|July 11, 2023
概括
甲状腺激素失衡,特别是亚临床甲状腺功能低下症,在慢性病中很常见. 这种情况会增加患者心血管疾病的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 甲状腺激素 (TH) 不平衡与慢性病 (CKD) 和末期病 (ESKD) 有关.
- 亚临床甲状腺功能低下症 (SCHT) 在CKD/ESKD患者中更为普遍,并显著增加心血管疾病 (CVD) 风险.
- 由于传统和非传统的风险因素,包括TH异常,CKD/ESKD患者面临更高的心血管疾病负担.
研究的目的:
- 审查CKD和甲状腺功能低下症之间的关系,专注于SCHT.
- 探索将SCHT与病患者心血管疾病负担增加的机制.
主要方法:
- 关于甲状腺功能和脏疾病研究的文献综述.
- 对CKD/ESKD群体中SCHT患病率的流行病学数据的分析.
- 检查连接TH,功能和心血管疾病的病理生理路径.
主要成果:
- 在CKD和ESKD患者中,SCHT是常见的并发症.
- 在这一群体中,SCHT是心血管疾病发病率和死亡率的独立风险因素.
- TH异常有助于在病中观察到的心血管疾病风险升高.
结论:
- 甲状腺激素功能障碍,特别是SCHT,是CKD和ESKD的一个重大问题.
- 解决TH失衡可能对减轻病患者心血管疾病风险至关重要.
- 需要对这些机制进行进一步的研究,以开发有针对性的疗法.
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