关于慢性非细菌性骨髓炎治疗反应和结果测量发展的最新情况
Shwetha Ramachandran1, Yongdong Zhao2, Polly J Ferguson1
1Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Current opinion in rheumatology
|July 11, 2023
概括
慢性非细菌性骨髓炎 (CNO) 是一种自身炎症性骨疾病. 目前正在制定新的标准和结果措施,以改善临床试验,并为这种疾病找到更好的治疗方法.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 自燃性炎症性疾病自燃性炎症性疾病
- 骨疾病 骨疾病
背景情况:
- 慢性非细菌性骨髓炎 (CNO) 是一种自身炎症性骨疾病,儿童的诊断越来越多.
- 在少数患者中发现遗传原因;然而,对非综合征性CNO的诊断缺乏特定的测试.
- 目前对CNO的治疗是经验性的,最佳的二线疗法仍然不清楚.
研究的目的:
- 审查慢性非细菌性骨髓炎 (CNO) 的最新治疗趋势.
- 评估开发CNO临床试验所必需的结果措施的进展情况.
主要方法:
- 关于CNO治疗和结果措施的最新研究的文献综述.
- 分析当前的诊断和治疗方法.
- 对CNO临床试验方法的进展评估.
主要成果:
- 由于越来越多的认识和先进的成像 (MRI),CNO诊断的数量正在增加.
- 瘤坏死因子抑制剂 (TNFi) 和双酸盐是NSAID耐药性CNO的常见二线治疗方法.
- 验证的分类标准,临床结果测量和成像标准正在接近完成.
结论:
- 标准化标准和结果测量对于在CNO进行强大的临床试验至关重要.
- 这些工具的开发将促进针对CNO的向药物的批准.
- 需要进一步的研究来澄清NSAID耐药性CNO的最佳治疗策略.
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