复发性多发性硬化症中的性饮食:患者的看法,试验后的饮食遵守和结果
Emma Wetmore1, Diana Lehner-Gulotta2, Brian Florenzo3
1Dept of Neurology, University of Virginia, Charlottesville, VA, USA; School of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Clinical nutrition (Edinburgh, Scotland)
|July 11, 2023
概括
大多数患有多发性硬化症 (MS) 的患者在试验结束后继续性饮食 (KDs),许多人采用了不那么严格的方法. 较大降低的BMI和疲劳预测继续坚持KDs.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 饮食干预 饮食干预
背景情况:
- 对于患有多发性硬化症 (MS) 的人来说,性饮食 (KD) 被认为是安全的和可以容忍的.
- 虽然KD在MS的临床和患者报告的好处已被记录,但在受控试验之外的长期可持续性仍然不清楚.
研究的目的:
- 评估患者在干预后对KD的看法.
- 在临床试验后确定KD的坚持率.
- 确定影响KDs在干预后继续存在的因素.
主要方法:
- 对65名复发性多发性硬化症患者进行了为期6个月的前性,意图治疗的KD干预.
- 干预后,3个月的随访评估了患者报告的结果,饮食回忆,临床测量和实验室值.
- 一项调查评估了持续的好处和影响持续使用KD的因素.
主要成果:
- 81%的受试者参加了为期3个月的随访;21%严格遵守KD,37%遵循自由化的KD.
- 在6个月内,BMI和疲劳的较大降低预测了KD延续的可能性更高.
- 随访3个月后,患者报告和临床结局仍然比基线显著改善,尽管略有减弱.
结论:
- 大多数受试者在干预后继续使用KD,许多人选择了不那么严格的碳水化合物限制.
- 在干预期间,BMI或疲劳的显著降低与继续严格遵守KD有关.
- 六个月的KD干预导致研究期间以外的饮食习惯持续变化.
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