呼出的气凝液中的乳酸盐及其与癌症的相关性:挑战,承诺和要求提供数据
Veronika Ruzsányi1, Miklós Péter Kalapos2
1Institute for Breath Research, University of Innsbruck, Innrain 66 and 80/82, Innsbruck, A-6020, Austria.
Journal of breath research
|July 11, 2023
概括
呼吸乳酸测量显示了癌症监测和治疗控制的前景. 然而,目前的检测可靠性和灵敏性限制了其临床使用,主要是作为晚期癌症的预后生物标志物.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 呼吸系统医学 呼吸系统医学
背景情况:
- 乳酸与癌症代谢有着固有的联系,这使其成为长期以来的研究兴趣.
- 呼气分析,包括挥发性有机化合物 (VOC) 和冷凝物,提供了对个体健康状况的洞察力.
研究的目的:
- 探索呼吸乳酸测量用于瘤诊断和治疗监测的潜力.
- 确定呼吸乳酸度测量技术的技术挑战和未来方向.
- 简要地讨论出口气凝结物 (EBC) 乳酸的非癌症应用.
主要方法:
- 对呼出的气息挥发性有机化合物 (VOC) 的分析.
- 对非挥发性有机物 (VOC) 的呼气凝结物 (EBC) 的分析.
- 对乳酸作为生物标志物的现有文献的审查.
主要成果:
- 呼吸乳酸测量是癌症查和监测的一个有前途的工具.
- 目前EBC乳酸检测的可靠性和灵敏性是不确定的,限制了临床应用.
- 血和EBC中的乳酸盐目前主要用于晚期癌症的生物标志物,提供预后而不是差异诊断价值.
结论:
- 呼出的呼吸凝聚物 (EBC) 乳酸具有癌症监测的潜力.
- 为了广泛的临床采用,需要进一步提高可靠性和灵敏度.
- 乳酸的当前作用主要是预后在晚期癌症病例.
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